A predictive signature for oxaliplatin and 5-fluorouracil based chemotherapy in locally advanced gastric cancer

Adjuvant chemotherapy(AC) plays a substantial role in the treatment of locally advanced gastric cancer (LAGC), but the response remains poor.We aims to improve its efficacy in LAGC.Therefore, we identified the expression of eight genes closely associated with platinum and fluorouracil metabolism (RRM1, RRM2, RRM2B, POLH, DUT, Collections TYMS, TYMP

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Control of cyclin C levels during development of Dictyostelium.

Cdk8 and its partner cyclin C form part of the mediator complex which links the basal transcription machinery to regulatory proteins.The pair are required for correct regulation of a subset of genes and have been implicated in control of Exfoliating Gloves development in a number of organisms including the social amoeba Dictyostelium discoideum.Whe

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